Q & A
FAQ
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Is there an age limit?
There is no defined age limit.
Age is not an issue for stem cell culture, so we will keep you informed of any changes to age restrictions while ensuring strict safety in order to treat as many people as possible. Regenerative medicine, which uses your own cells and blood, is a treatment with very little burden on the body. Our hope is that regenerative medicine will help more people lead a fulfilling life. If you have symptoms that are concerning, please feel free to contact us. -
What is supernatant?
It is not yet approved by the Ministry of Health, Labor and Welfare, so anyone can handle the supernatant fluid. It is the supernatant fluid produced in the process of culturing mesenchymal stem cells.
Although it is a supernatant fluid, it contains cytokines and exosomes called growth factors contained in mesenchymal stem cells, and has been shown to have effects similar to those of regenerative medicine. -
What effects can supernatant have?
Nasal drops, eye drops and inhalation have been effective.
- ◎Effect of increasing physical strength can be seen (e.g., increased bench press weight)
- ◎No more blurred vision
- ◎Improvement in sleep disorder
- ◎Change in the quality of sleep
- ◎Thinking faster
- ◎Speaking more clearly
- ◎Improvement and prevention of rhinitis, empyema, and hay fever
- ◎People with poor eyesight can see recovery vision
- ◎Improvement of cataracts
- ◎Glaucoma prevention
- ◎Activation of the blood and circulatory system
- ◎Improvement of sensitivity to cold
- ◎Effective for hyperactivity and hoarseness in children as it reaches the frontal lobe quickly
- ◎Joint pain
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What kind of diseases and symptoms does it work for?
It is expected to restore functions of the body that have deteriorated due to injured organs or illness.
■Neurodegenerative disease
■Headache, autonomic imbalance, aftereffects of cerebral hemorrhage, aftereffects of cerebral infarction, etc.
■Neurodegenerative disease ■ALS, Alzheimer's disease, Parkinson's disease, etc.
■Cardiovascular disease
■Aftereffects of myocardial infarction, idiopathic atrial fibrillation, hypertension, arrhythmia, etc.
■Respiratory disease
■COPD, bronchiectasis, asthma, etc.
■Metabolic disease
■Diabetes, hyperlipidemia, kidney disease, gout, chronic renal failure, etc.
■Digestive disorders
■Liver dysfunction, reflux esophagitis, enteritis, chronic cholecystitis, etc.
■Immune disease
■Atopic dermatitis, urticaria, Sjögren's syndrome, allergic predisposition, etc.
■Locomotive disease
■Ligament damage, muscle strain, lumbar spondylosis, osteoarthritis, pain relief in various places, etc.
■Others
■Menopausal disorder, periodontal disease, erectile dysfunction, aftereffects of new coronavirus infection, health promotion, etc.
■Beauty
■Anti-aging for the skin of the face and hands, hair loss treatment -
What is the difference between autologous supernatant and allogeneic supernatant?
Simply put, the autologous supernatant is the supernatant made using your own cells, while allogeneic supernatant is made using someone else's cells. The autologous one is derived from your own cells, so it is highly safe and has no risk. The allogenic one may or may not list the donor's age and gender. Since there is cellular copy transfer that is not at your own cellular level but only at doner’s, there is also the advantage of using both the allogenic and autologous supernatants together.
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The genuine regenerative medicine delivered by re:sai
We have partnered with a highly safe clinic that has completed procedures required for providing regenerative medicine and has a culture facility on site. The clinic has a supernatant production zone in the culture facility, where only supernatant is carefully produced separately from cell culture used in regenerative medicine, and has succeeded in producing safe and high quality supernatant. We provide genuine “autologous stem cell supernatant” extracted from supernatant components made from your own stem cells. Even for allogeneic supernatant, the quality is of course properly controlled, and the dedicated cultivator figures out the right timing in the process of production and collects the supernatant fluid with excellent skills. Therefore, it is very safe and secure to use. We deliver genuine “regenerative medicine” and “stem cell supernatant” using the properties of stem cells to our customers.
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What are exosomes?
They are granular substance secreted by cells. They are thought to reflect the characteristics of the cells from which they were secreted. Exosomes secreted from cells are not only present between cells, but are also present in body fluids (blood, cerebrospinal fluid, urine, etc.) and circulate throughout the body. They act like a carrier of cells.
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I have recently heard of exosomes, but how are they different from the supernatant?
上The supernatant contains cytokines and exosomes. Some cytokines, such as interleukin, are used individually as medicine. Exosomes are extracellular vesicle containing proteins, lipids, and mRNA. In addition, these are contained in the supernatant fluid.
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At what age should we start the treatment?
Basically, there is no correct age for the treatment, and it is possible to start even from an old age. However, it is said that women want to try before the age of 40 and men around 50, before menopause occurs. However, interleukin have been reported to affect childbearing, and it may be necessary to consider refraining from treatment at childbearing age.
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Is it safe to use adipose stem cells from other people? Also, how are they stored?
Since the supernatant does not contain cells themselves, there is no risk of immune rejection that could occur in blood transfusions and organ transplants. We produce adipose-derived stem cell culture supernatant using allogeneic or autologous cells and store it frozen. At the culture facility, it is stored and managed at -80 to -50 degrees Celsius and can be stored at home in an ordinary home freezer. Since the supernatant does not contain cells, it can be administered by infusion under the supervision of a medical institution, whether it is originated from someone else or your own. When giving infusion of stem cells in regenerative medicine, we use autologous stem cells that have been extracted and cultured from your own cells. Adipose-derived stem cells have the functions of “differentiation ability” and “self-renewal ability”. In addition, they have an "anti-inflammatory effect" that reduces inflammation and suppresses activated immune cells, and an "immune adjustment effect" that adjusts the immune balance that has collapsed due to autoimmune diseases. Another advantage is that administration of cord blood-derived or bone-derived stem cells poses the least damage or risk to the host.
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Does it place a burden on the body?
Regenerative medicine is a medical technology with great benefits, as it is a treatment that does not place a burden on the body and can be expected to be effective for various symptoms without the risk of major side effects.
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I currently go to the hospital regularly and take medication, but can I still receive treatment?
Regenerative medicine is a treatment that uses the most of the patient's own ability to repair and regenerate the body naturally. It can be expected to be effective for those who have anxiety because their current treatment or medication is not working.
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I can’t decide to receive the treatment. Can I discuss it in detail?
rasai will talk with you until your understanding of regenerative medicine is expanded and you are satisfied with the correct knowledge. We offer face-to-face, online, and email support.
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Could you tell me more about the progress of those who have been treated?
We have helped many people to get the most out of regenerative medicine. From many cases, we will talk about those who have realized the effect and those who have become repeat customers.
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May I consult with my doctor?
Regenerative medicine is a new medical technology. There are many people who receive treatment after having a thorough consultation with their trusted doctor.
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Does it have a preventive effect against scary diseases, etc.?
Stem cells are said to have many functions, such as wound healing, immune regulation, and nerve regeneration, and be effective in treating all kinds of diseases. They are also expected to be used as a preventive treatment for these diseases.
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Why is the treatment cost so high? Is it not covered by insurance?
In order to be covered by insurance, the national approval is required. The review process takes a long time, and cutting-edge medical technology cannot be immediately covered by insurance. Even if the treatment is provided overseas, it needs to be reviewed again in Japan.
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Does regenerative medicine cause no harm to the body?
There is no risk of rejection response as the patient's own cells are administered. In addition, our affiliated clinic submitted a provision plan for Class II regenerative medicine to the Ministry of Health, Labor and Welfare, which was accepted. As a result, we are now able to provide cutting-edge regenerative medicine that had been difficult to receive in Japan. Please be assured that we have a system in place to provide safe regenerative medicine according to formal procedures after undergoing a strict review by the Certified Special Committee for Regenerative Medicine based on the Act on the Safety of Regenerative Medicine.
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Is it always effective?
The effects of the treatment will be felt. However, as is the case with all treatments, there are individual differences. Also, it cannot be said that all can be cured in a single treatment. We believe that multiple treatments are more highly effective than a single treatment. We will provide the most suitable treatment for each person according to his or her symptoms and conditions.
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Do I need a reservation?
We have a reservation system to allow enough time for each patient and to reduce waiting time. Reservations can be made by either phone or email.
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Do I need a letter of reference?
A letter of reference is not required. However, if you received treatment or surgery in the past, it may be necessary to confirm what kind of treatment you received. In such cases, we may ask you to provide a letter of reference or something else that explains the details of the treatment or surgery.
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Are there any cases where regenerative medicine is not available?
If an infection is found in the blood test before the treatment, you may not be able to receive it.
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Is it eligible for medical expenses deduction?
It becomes often eligible for medical expenses deduction. Our clinic also issues necessary receipts. Whether the medical expenses are deductible depends on regional tax offices. For details, please contact the tax office in your jurisdiction directly.
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What are mesenchymal stem cells?
In the process of researching the properties of various "tissue stem cells," it was discovered that our bodies contain stem cells that are highly capable of differentiating into various types of cells, just like the ES cells in fertilized eggs. They were first discovered in bone marrow in the 1960s, then in adipose tissue in the 2000s, and both are called "mesenchymal stem cells. "Mesenchymal stem cells have a very high ability to divide and proliferate (proliferative ability), and have so-called "pluripotency" to differentiate into not only cells of one lineage but also nerves, muscles, fat, bones, etc.。
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What are the benefits of regenerative medicine using stem cells?
There are already many treatment results, and it has been used in the treatment of diseases and injuries. It is known to be a safe treatment with few side effects.
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What can we expect from regenerative medicine and stem cell treatment?
You can expect a fundamental treatment for a difficult disease. If regenerative medicine advances, it will be possible to treat the underlying cause of chronic disease. Not only that, there are great expectations for the possibility of creating whole organs such as kidneys and hearts.
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How long does the treatment take?
There are individual differences in the cultivation period of stem cells, but we carefully cultivate stem cells for about two months at our affiliated culture facility. Only occasionally, number of cells does not increase in cultivation. In that case, we will take cells again and cultivate them to increase to around 150 million.
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I see regenerative medicine on TV and in magazines, but it is too difficult to understand.
Regenerative medicine is an advanced medical treatment that holds great promise for the near future. We regard it our mission to provide you with detailed information in an easy-to-understand manner. Please feel free to ask questions.
Regenerative medicine is an advanced medical treatment that holds great promise for the near future. We regard it our mission to provide you with detailed information in an easy-to-understand manner. Please feel free to ask us any questions you may have.